1. Understanding the gluten problem

Gluten proteins – mainly present in wheat, barley and rye – contain certain peptides that are difficult for humans to digest.

In sensitive individuals, these peptides cause inflammation leading to unpleasant symptoms such as bloating and abdominal discomfort. For people with celiac disease, they cause immune reactions with more severe symptoms and long-term complications.

Avoiding gluten is part of the solution, but even then cross-contamination is surprisingly often a problem. Research shows that even with a strict gluten-free diet, people can be accidentally exposed to 200 to 3,000 mg of gluten per day¹²³.

2. The power of a specialized enzyme

Tolerase® G is a scientifically developed prolyl endoprotease. Unlike general digestive enzymes, this enzyme specifically targets the problematic parts of the gluten protein. Here is a simplified explanation of how it works:

Activation in the stomach: As soon as you swallow the capsule, Tolerase® G begins working in the acidic environment of your stomach – an environment in which many other enzymes lose their action.⁴⁵

Targeted breakdown: The enzyme specifically targets and breaks down the immune-active (reaction-inducing) fragments of gluten.⁵⁶

Fast action: Studies show that the enzyme can break down up to 86% of these gluten fragments within 10 minutes – even before they reach the small intestine.⁷⁸

3. Research & clinical confirmation

Collaborative development: Royal DSM, a globally renowned and scientifically based company, produces Tolerase® G according to strict quality and safety standards.

Clinical observations: Several studies highlight the exceptional performance of Tolerase® G:

1. In a gastrointestinal model, Tolerase® G reduced immune-active gluten fragments by more than 86%, providing essential protection for people with gluten hypersensitivity.⁸

• In direct comparisons, Tolerase® G consistently outperformed other commercially available enzymes. It broke down gluten fragments more effectively and consistently in a variety of meal situations, providing reliable gluten control.⁶⁷
• Resistant to acidic conditions: Where many enzymes break down in the stomach, Tolerase® G is specially designed to withstand these conditions and remain effective.⁴
• Trials with gluten-sensitive individuals showed that Tolerase® G significantly reduced gluten immunogenicity in real meal situations, outperforming placebos and other supplements.⁷⁸